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The FDA announced the approval of an new weight-loss drug on Sept. 11, 2014. The drug name is Contrave.

Using two separate drugs to shed weight can be very effective you'll find combinations while watching FDA now awaiting approval. When dealing with fat loss and the individuals who go through it you need to err along the side of caution and allow FDA do its job and demand some investigation be done in order that the public recognizes the side effects and perils associated with the medications before we take them. Keep in mind that drug companies will be in business to generate income and that they would say almost anything to keep people on their medications.

Researchers discovered that participants investing in this drug for the year, dropped excess weight within four weeks and have kept the load off through the 56 weeks with the study. Contrave is a combination with the drugs naltrexone and bupropion, which generally seems to reflect a fresh trend of weight-loss drugs which might be made up of many active ingredient, that might make them more efficient and safer.

Combo-pilling will be the newest fad or better yet the newest in the future under scrutiny and therefore it is just more publicly known although in the past, comb-pilling for losing weight has been around since the eighties. The biggest reason that employing a combination of pills has become popular is the fact that by right now there aren't long term prescription weight loss supplements that have been licensed by the FDA other than orlistat. The truly disturbing part is always that doctors are prescribing these combinations of medications however some of the combinations are already rejected or have yet to be licensed by the FDA.

Seizures are a side effect with Contrave and really should not be taken in people with seizure disorders. The drug may also raise blood pressure level and heartbeat, and shouldn't be used in people with a history of heart attack or stroke in the last six months. Blood pressure and pulse should also be measured before commencing the drug and throughout therapy with the drug.

The FDA also warned that Contrave can raise blood pressure levels and pulse rate and must stop used in patients with uncontrolled high blood pressure level, in addition to by you aren't heart-related and cerebrovascular (circulatory dysfunction impacting the mind) disease. Patients having a history of heart attack or stroke in the previous six months, life-threatening arrhythmias, or congestive heart failure were excluded from your clinical trials. Those taking Contrave must have their heart-rate and pulse monitored regularly. In addition, since compound includes bupropion, Contrave comes having a boxed warning to alert physicians and patients for the increased risk of suicidal thoughts and behaviors associated with antidepressant drugs. The warning also notes that serious neuropsychiatric events happen to be reported in patients taking bupropion for stopping smoking.


Suboxone is made up of two drugs; buprenorphine and naloxone. The naloxone is irrelevant in the event the addict uses the medication properly, but in the event the tablet is dissolved in water and injected the naloxone can cause instant withdrawal. When suboxone is employed correctly, the naloxone is destroyed inside the liver shortly after uptake from the intestines and it has no therapeutic effect. Buprenorphine will be the active substance; it can be absorbed beneath the tongue (and through the mouth) but destroyed from the liver if swallowed. There is a formulation of buprenorphine without naloxone called subutex; I manipulate this formulation if the patient has apparent problems from naloxone, including headaches after dosing with suboxone. I also have treated addicts who may have had gastric bypass, the location where the first area of the intestine is bypassed and also the stomach contents empty in to a more distal section of the small intestine. In such cases the naloxone escapes ?first pass metabolism', the method with normal anatomy where the drug is taken up through the duodenum and transferred straight away to the liver by the portal vein, where it is quickly and completely destroyed. After gastric bypass naloxone can be adopted by servings of the intestine that aren't served from the portal system, causing blood levels of naloxone sufficient to cause brief, relatively mild withdrawal symptoms.